Associations 16–50 (except Liechtenstein) each had three teams qualify.

Associations 6–15 and 51–55 each had two teams qualify.

Association 1 (Spain) did not have any team qualify for this season, as the team which would have participated, Villarreal, won the 2020–21 UEFA Europa League and earned a place in the 2021–22 UEFA Champions League.

Associations 1–5 each had one team qualify.

The association ranking based on the UEFA country coefficients was used to determine the number of participating teams for each association: Association team allocation Ī total of 181 teams from 54 of the 55 UEFA member associations participated in the 2021–22 UEFA Europa Conference League (the exception being Spain, as none of their teams finished third in the Europa League group stage). Therefore, if in a two-legged tie, two teams scored the same number of aggregate goals, the winner was not decided by the number of away goals scored by each team, but always by 30 minutes of extra time, and if the two teams scored the same number of goals in extra time, the winner was decided by a penalty shoot-out. On 24 June 2021, UEFA approved the proposal to abolish the away goals rule in all UEFA club competitions, which had been used since 1965.

This season was the first since 1999–2000 (the first season after the dissolution of the UEFA Cup Winners' Cup) where three major European club competitions ( UEFA Champions League, UEFA Europa League, and UEFA Europa Conference League) took place. As winners, Roma automatically qualified for the 2022–23 UEFA Europa League group stage, although they had already done so through their league position.

The final was played at the Arena Kombëtare in Tirana, Albania, with Roma defeating Feyenoord 1–0. The 2021–22 UEFA Europa Conference League was the inaugural season of the UEFA Europa Conference League, Europe's tertiary club football tournament organised by UEFA.

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